Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Organization of African Unity Street, Abbassia, Cairo, 11566, Egypt.
Eur J Drug Metab Pharmacokinet. 2022 Jan;47(1):1-18. doi: 10.1007/s13318-021-00731-y. Epub 2021 Oct 23.
Flavonoids are phytochemicals that are well known for their beneficial pharmacological properties. Diosmin is a flavone glycoside derived from hesperidin, a flavanone abundantly found in citrus fruits. Daflon is an oral phlebotonic flavonoid combination containing diosmin and hesperidin (9:1) that is commonly used for the management of blood vessel disorders. After oral administration, diosmin is converted to diosmetin, which is subsequently absorbed and esterified into glucuronide conjugates that are excreted in the urine. Pharmacological effects of diosmin have been investigated in several in vitro and in vivo studies, and it was found to possess anti-inflammatory, antioxidant, antidiabetic, antihyperlipidemic, and antifibrotic effects in different disease models. Diosmin also demonstrated multiple desirable properties in several clinical studies. Moreover, toxicological studies showed that diosmin has a favorable safety profile. Accordingly, diosmin is a potential effective and safe treatment for many diseases. However, diosmin exhibits inhibitory effects on different metabolic enzymes. This encourages the investigation of its potential therapeutic effect and safety in different diseases in clinical trials, while taking potential interactions into consideration.
类黄酮是一种植物化学物质，以其有益的药理特性而闻名。地奥司明是一种源自橙皮苷的黄酮糖苷，橙皮苷是一种在柑橘类水果中大量存在的黄烷酮。达肝素是一种含有地奥司明和橙皮苷（9:1）的口服血管舒缓黄酮类化合物混合物，常用于治疗血管疾病。口服后，地奥司明转化为地奥汀，然后被吸收并酯化形成葡萄糖醛酸缀合物，从尿液中排出。地奥司明的药理作用已在多项体外和体内研究中进行了研究，结果发现它在不同的疾病模型中具有抗炎、抗氧化、抗糖尿病、抗高血脂和抗纤维化作用。地奥司明在多项临床研究中也表现出多种理想特性。此外，毒理学研究表明地奥司明具有良好的安全性。因此，地奥司明是治疗许多疾病的一种有潜力的有效且安全的药物。然而，地奥司明对不同的代谢酶具有抑制作用。这鼓励在临床试验中研究其在不同疾病中的潜在治疗效果和安全性，同时考虑到潜在的相互作用。
