Lombardi Comprehensive Cancer Center, Georgetown University School of Medicine, Research Building, W326A, 3970 Reservoir Rd, NW, Washington, DC 20057, USA.
J Community Health. 2012 Apr;37(2):335-43. doi: 10.1007/s10900-011-9450-y.
Clinical trials are considered the gold standard of evidence about the efficacy of cancer prevention, early detection, and treatment interventions. A paucity of data exists on determinants of clinical trial participation in the growing US Latino population despite poor cancer outcomes in this group. This study seeks to describe correlates of awareness of and willingness to participate in clinical trials among largely Central, North, and South American Latinos using safety-net clinics. Between June 2007 and November 2008, we conducted an interviewer-administered, Spanish-language cross-sectional survey (n = 944). Logistic regression was used to assess effects of health information sources and psychosocial variables on awareness of and intention to participate in clinical trials. Analyses were completed in spring 2010. While only 48% knew what a clinical trial was, when explained, 65% indicated a willingness to participate. Providers were the most common source of health information. Use of Internet for health information, trust in health information, and higher education each independently increased the odds of clinical trial awareness, but obtaining information from providers did not. Contacting the Cancer Information Service and psychosocial factors were each independently associated with intent to join a clinical trial, while demographic factors were not. Information channels such as the Internet may be effective in conveying clinical trial information to Latinos. Providers being cited as the most common source of health information but not being associated with knowledge about or intent to participate in trials suggests a missed opportunity for communication to this population.
临床试验被认为是评估癌症预防、早期发现和治疗干预措施疗效的金标准。尽管美国拉美裔人群的癌症预后较差，但关于该人群参与临床试验的决定因素的数据却很少。本研究旨在描述利用医疗服务匮乏人群诊所，了解和参与临床试验的意识与意愿在中、北美洲和南美洲拉美裔人群中的相关因素。2007 年 6 月至 2008 年 11 月，我们进行了一次西班牙语的、调查员管理的、横断面调查（n=944）。采用逻辑回归分析评估健康信息来源和心理社会变量对临床试验意识和参与意愿的影响。分析于 2010 年春季完成。尽管只有 48%的人知道临床试验是什么，但当被解释后，65%的人表示愿意参与。医疗服务提供者是最常见的健康信息来源。使用互联网获取健康信息、对健康信息的信任度和更高的教育水平均独立增加了对临床试验的认知几率，但从提供者处获取信息则不然。与癌症信息服务联系以及心理社会因素均与参与临床试验的意愿独立相关，而人口统计学因素则不然。互联网等信息渠道可能在向拉美裔人群传达临床试验信息方面有效。虽然提供者被认为是最常见的健康信息来源，但与对临床试验的了解或参与意愿无关，这表明向该人群进行沟通的机会被错失了。
