Cancer Prevention and Control Program, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3800 Reservoir Road, Washington, DC 20057, USA.
J Community Health. 2013 Aug;38(4):652-9. doi: 10.1007/s10900-013-9660-6.
Latinos tend to be under-represented in cancer research and in bio-repositories. We conducted a Spanish-language, interviewer-administered cross-sectional survey of 331 foreign-born Latinos from Central and South America attending safety-net clinics in order to describe factors associated with knowledge about and intention to provide bio-specimens for research purposes. We used logistic regression and multiple imputation methods to evaluate associations between socio-cultural measures, medical trust, demographics, as well as knowledge about and intentions to provide bio-specimens. Almost half (47 %) of respondents knew what bio-specimens were, and 67 % said that they would provide a specimen after being given information about what this involved; this increased to 72 % among those with prior knowledge. Controlling for covariates, Latinos with a high school education and above were more likely to know what a bio-specimen was and to say they would provide bio-specimens than were those with lower levels of education [adjusted OR (aOR) 2.85, 95 % CI 1.37-5.96; and 3.49, 95 % CI 1.41-8.63, p ≤ 0.01, respectively]. Those with greater social integration were more likely to know about bio-specimens than those with less integration (aOR 2.54, 95 % CI 1.45-4.46, p = 0.001). Higher endorsement of family values was independently associated with intent to give bio-specimens (aOR 1.11, 95 % CI 1.02-1.20, p = 0.017 per five-point increase in "familism" score). Medical mistrust was not related to intentions to provide specimens. Our results suggest that interventions to increase willingness to provide bio-specimens could leverage trusted clinics or social networks and should consider individuals' education and socio-cultural perspectives.
拉丁裔在癌症研究和生物样本库中代表性不足。我们对来自中美洲和南美洲的 331 名在接受服务人群诊所就诊的外国出生的拉丁裔进行了西班牙语、调查员管理的横断面调查，以描述与知识和提供生物样本进行研究目的的意愿相关的因素。我们使用逻辑回归和多重插补方法来评估社会文化措施、医疗信任、人口统计学因素以及对提供生物样本的知识和意图之间的关联。近一半（47%）的受访者知道生物样本是什么，并且 67%的受访者表示在了解了相关信息后会提供样本；在有相关知识的受访者中，这一比例增加到 72%。在控制了协变量后，受过高中及以上教育的拉丁裔更有可能知道生物样本是什么，并且更有可能表示他们会提供生物样本，而受教育程度较低的人则不然[调整后的比值比（aOR）为 2.85，95%置信区间（CI）为 1.37-5.96；3.49，95%CI 为 1.41-8.63，p≤0.01]。社会融合程度较高的人比融合程度较低的人更有可能了解生物样本[aOR 为 2.54，95%CI 为 1.45-4.46，p=0.001]。对家庭价值观的更高认可度与提供生物样本的意愿独立相关[aOR 为 1.11，95%CI 为 1.02-1.20，p=0.017，“家庭主义”得分每增加五分]。医疗不信任与提供样本的意愿无关。我们的研究结果表明，增加提供生物样本意愿的干预措施可以利用值得信赖的诊所或社交网络，并应考虑个体的教育和社会文化观点。
