Department of Psychology, Columbia University, New York, NY, USA.
Bioessays. 2011 Sep;33(9):662-8. doi: 10.1002/bies.201100060. Epub 2011 Aug 1.
Imprinted genes (IGs) are expressed or silenced according to their parent-of-origin. These genes are known to play a role in regulating offspring growth, development and infant behaviors such as suckling and ultrasonic calls. In adults, neurally expressed IGs coordinate several behaviors including maternal care, sex, feeding, emotionality, and cognition. However, despite evidence from human psychiatric disorders and evolutionary theory that maternally and paternally expressed genes should also regulate social behavior, little empirical data from mouse research exists. This paper discusses data from a recent study (Garfield et al., 2011) that the IG Grb10 governs unique aspects of mouse social behavior and interprets the relevance of these findings for the future of this field.
印迹基因（IGs）根据其亲源表达或沉默。这些基因已知在调节后代的生长、发育和婴儿行为（如吮吸和超声波呼叫）方面发挥作用。在成人中，神经表达的 IGs 协调包括母性行为、性行为、喂养、情感和认知在内的多种行为。然而，尽管有人类精神疾病和进化理论的证据表明，母系和父系表达的基因也应该调节社会行为，但来自小鼠研究的实证数据很少。本文讨论了最近一项研究（Garfield 等人，2011）的数据，该研究表明 IG Grb10 控制着小鼠社会行为的独特方面，并解释了这些发现对该领域未来的相关性。
