Uskova N V, Antelava N A
Farmakol Toksikol. 1977 Sep-Oct;40(5):521-4.
A comparative characterization of a tremor produced by aceclidine (0.5--200 mg/kg), arecoline (1--30 mg/kg) and nicotine (0.1--8 mg/kg) in rats of different age is given and the influence on the tremor of atropine sulphate (1--100 mg/kg) and scopolamine hydrobromide hydrobromide (2.5 mg/kg) described. The common character of effects produced by aceclidine and arecoline was ascertained. The tremor develops in rats aged 7--8 days and its maximum duration is in rattlings of junior and medium age. M-cholino-lytics either prevent or alleviate the tremor, lacrimation and salivation induced by aceclidine or arecoline in rats of all age categories. The aceclidine model is recommended for studying the central and peripheral M-cholinergic processes in rats of various age groups.
本文给出了不同年龄大鼠由醋甲胆碱（0.5 - 200mg/kg）、槟榔碱（1 - 30mg/kg）和尼古丁（0.1 - 8mg/kg）引起的震颤的比较特征，并描述了硫酸阿托品（1 - 100mg/kg）和氢溴酸东莨菪碱（2.5mg/kg）对震颤的影响。确定了醋甲胆碱和槟榔碱产生作用的共同特征。震颤在7 - 8日龄大鼠中出现，其最长持续时间出现在幼年和中年大鼠中。M胆碱能阻断剂可预防或减轻所有年龄段大鼠由醋甲胆碱或槟榔碱引起的震颤、流泪和流涎。推荐使用醋甲胆碱模型研究不同年龄组大鼠的中枢和外周M胆碱能过程。
