Sprints A M, Vinogradov V V, Kolpinskaia N D
Farmakol Toksikol. 1988 Mar-Apr;51(2):36-8.
In experiments on rats the degrees of the central m-cholinergic blocking (by the ability to suppress arecoline-induced tremor /AT/) and dopamine-potentiating (by potentiation of apomorphine-induced stereotypy (AS] effects of amizyl, glypine, scopolamine and 4-methylpyperidylbenzylate (4-MP) and an esther of phenylcyclopentylglycolinic acid and tropanol (PCT) were compared. It was found that with respect to AS and AT one can distinguish central m-cholinergic blocking agents with milddly (PCT, glypine) and strongly (4-MP, amizyl) dopamine-potentiating properties. None of these compounds administered in the doses corresponding to ED84 by AS influenced nicotine-induced tremor in rats.
在大鼠实验中，比较了阿米齐尔、格列平、东莨菪碱和4-甲基哌啶基苄酯（4-MP）以及苯基环戊基甘醇酸与托烷醇的酯（PCT）的中枢M胆碱能阻断程度（通过抑制槟榔碱诱发震颤的能力/AT/）和多巴胺增强程度（通过增强阿扑吗啡诱发的刻板行为/AS/）。结果发现，就AS和AT而言，可以区分出具有轻度（PCT、格列平）和强烈（4-MP、阿米齐尔）多巴胺增强特性的中枢M胆碱能阻断剂。以AS对应的ED84剂量给药时，这些化合物均未影响大鼠尼古丁诱发的震颤。
