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堪萨斯大学高通量筛选实验室。第二部分:通过尖端筛选技术实现合作药物发现伙伴关系。

The University of Kansas High-Throughput Screening Laboratory. Part II: enabling collaborative drug-discovery partnerships through cutting-edge screening technology.

机构信息

High-Throughput Screening Core Facility, Structural Biology Center, University of Kansas, Lawrence, KS 66047, USA.

出版信息

Future Med Chem. 2011 Jul;3(9):1101-10. doi: 10.4155/fmc.11.84.

Abstract

The University of Kansas High-Throughput Screening (KU HTS) core is a state-of-the-art drug-discovery facility with an entrepreneurial open-service policy, which provides centralized resources supporting public- and private-sector research initiatives. The KU HTS core was established in 2002 at the University of Kansas with support from an NIH grant and the state of Kansas. It collaborates with investigators from national and international academic, nonprofit and pharmaceutical organizations in executing HTS-ready assay development and screening of chemical libraries for target validation, probe selection, hit identification and lead optimization. This is part two of a contribution from the KU HTS laboratory.

摘要

堪萨斯大学高通量筛选(KU HTS)核心是一个拥有创业型开放式服务政策的最先进的药物发现设施,为公共和私营部门的研究计划提供集中资源支持。KU HTS 核心于 2002 年在 NIH 拨款和堪萨斯州的支持下在堪萨斯大学成立。它与来自国内外学术、非营利和制药组织的研究人员合作,进行高通量筛选就绪的测定开发和化学文库筛选,以进行靶标验证、探针选择、命中鉴定和先导优化。这是 KU HTS 实验室的贡献的第二部分。

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