FAS 和 FAS 配体多态性与汉族人群腰椎间盘退变易感性和严重程度的关联。
Association of FAS and FAS ligand polymorphisms with the susceptibility and severity of lumbar disc degeneration in Chinese Han population.
机构信息
Department of Radiology, The First Affiliated Hospital of Guangzhou Medical College, P.R. China.
出版信息
Biomarkers. 2011 Sep;16(6):485-90. doi: 10.3109/1354750X.2011.598563. Epub 2011 Aug 1.
CONTEXT
Apoptosis is involved in the mechanism of lumbar disc degeneration (LDD).
OBJECTIVE
We aim to determine whether the polymorphisms of FAS and FASL are associated with the presence and severity of LDD.
METHODS
A total of 348 patients with LDD and 215 healthy controls were genotyped.
RESULTS
Patients with LDD showed higher frequency of-1377GA and AA, as well as-844CT and TT genotypes than normal controls. These genotypes were found to be associated with the risk of higher grades of LDD.
CONCLUSION
The polymorphisms of FAS and FASL may be associated with the presence and severity of LDD.
背景
细胞凋亡参与腰椎间盘退变（LDD）的发生机制。
目的
我们旨在确定 FAS 和 FASL 的多态性是否与 LDD 的存在和严重程度相关。
方法
共对 348 例 LDD 患者和 215 例健康对照者进行了基因分型。
结果
与正常对照组相比，LDD 患者的-1377GA 和 AA 以及-844CT 和 TT 基因型频率更高。这些基因型与 LDD 严重程度较高的风险相关。
结论
FAS 和 FASL 的多态性可能与 LDD 的存在和严重程度相关。
Zotero 插件