Panic & Respiration Laboratory, Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Neuropharmacology. 2012 Jan;62(1):125-34. doi: 10.1016/j.neuropharm.2011.07.024. Epub 2011 Jul 27.
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive procedure whereby a pulsed magnetic field stimulates electrical activity in the brain. Anxiety disorders are the most common of all mental health problems for which effective, mechanism-based treatments remain elusive. Consequently, more advanced non-invasive therapeutic methods are required. A possible method to modulate brain activity and potentially viable for use in clinical practice is rTMS. Here, we focus on the main findings of rTMS from animal models of anxiety and the experimental advances of rTMS that may become a viable clinical application to treat anxiety disorders, one of the most common causes of disability in the workplace in the world. Key advances in combining rTMS with neuroimaging technology may aid such future developments. This article is part of a Special Issue entitled 'Anxiety and Depression'.
重复性经颅磁刺激（rTMS）是一种非侵入性程序，通过脉冲磁场刺激大脑中的电活动。焦虑障碍是所有心理健康问题中最常见的，而有效的、基于机制的治疗方法仍然难以捉摸。因此，需要更先进的非侵入性治疗方法。一种可能的调节大脑活动的方法，并且可能适用于临床实践，是 rTMS。在这里，我们关注 rTMS 在焦虑动物模型中的主要发现，以及 rTMS 的实验进展，这可能成为治疗焦虑障碍的一种可行的临床应用，焦虑障碍是世界上工作场所最常见的残疾原因之一。将 rTMS 与神经影像学技术相结合的关键进展可能有助于未来的发展。本文是特刊“焦虑和抑郁”的一部分。
