Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California at Los Angeles Medical Center, United States.
Curr Opin Microbiol. 2011 Aug;14(4):406-11. doi: 10.1016/j.mib.2011.07.004. Epub 2011 Jul 30.
Clinical hallmarks of mucormycosis infections include the unique susceptibility of patients with increased available serum iron, the propensity of the organism to invade blood vessels, and defective phagocytic function. These hallmarks underscore the crucial roles of iron metabolism, phagocyte function, and interactions with endothelial cells lining blood vessels, in the organism's virulence strategy. In an attempt to understand how Mucorales invade the host, we will review the current knowledge about interactions between Mucorales and the host while evading phagocyte-mediated killing. Additionally, since iron is an important determinant of the disease, we will focus on the role of iron on these interactions. Ultimately, a superior understanding of the pathogenesis of mucormycosis will enable development of novel therapies for this disease.
增加的血清铁含量使患者具有独特的易感性、该生物侵袭血管的倾向，以及吞噬功能缺陷。这些特征突出了铁代谢、吞噬细胞功能以及与血管内皮细胞相互作用在该生物毒力策略中的关键作用。为了了解毛霉目如何入侵宿主，我们将回顾目前关于毛霉目与宿主相互作用以及逃避吞噬细胞介导的杀伤的知识。此外，由于铁是疾病的一个重要决定因素，我们将重点关注铁在这些相互作用中的作用。最终，对粘质霉病发病机制的更好理解将能够为这种疾病开发新的治疗方法。
