Department of Clinical Pharmacy, University of Tennessee Health Science Center, 910 Madison Ave, Memphis, TN 38163, USA.
JPEN J Parenter Enteral Nutr. 2011 Sep;35(5 Suppl):44S-51S. doi: 10.1177/0148607111413771. Epub 2011 Aug 1.
Obesity compounds the metabolic response to critical illness and augments the consequences of overfeeding. Effective monitoring is essential for the prevention of, or to avoid, worsening of preexistent morbidities associated with obesity during the implementation of specialized nutrition support. This monitoring should guide the clinician toward the selection of appropriate therapeutic options to reduce complications from significant hyperglycemia, dyslipidemia, hypercapnia, fluid overload, and worsening of hepatic steatosis. Conventional nutrition outcome markers should be employed, with their limitations understood, when used for the critically ill obese patient.
肥胖会加重危重病患者的代谢反应，并加剧过度喂养的后果。有效的监测对于预防或避免肥胖相关的预先存在的合并症在实施专门的营养支持期间恶化至关重要。这种监测应该指导临床医生选择合适的治疗方案，以减少严重高血糖、血脂异常、高碳酸血症、液体超负荷和肝脂肪变性恶化等并发症。在用于危重病肥胖患者时，应使用常规的营养结局标志物，并了解其局限性。
