Bairwa Nirmal K, Sethiya Neeraj K, Mishra S H
Herbal Drug Technology Laboratory, Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda, Vadodara, Gujarat - 390 001, India.
Pharmacognosy Res. 2010 Jan;2(1):26-30. doi: 10.4103/0974-8490.60584.
The present study reports protective activity of ethyl acetate fraction of methanol extract of stem bark of Ceiba pentandra against paracetamol-induced liver damage in rats. The ethyl acetate fraction (400 mg/kg) was administered orally to the rats with hepatotoxicity induced by paracetamol (3 gm/kg). Silymarin (100 mg/kg) was used as positive control. High performance thin layer chromatography (HPTLC) fingerprinting of ethyl acetate fraction revealed presence of its major chemical constituents. A significant (P < 0.05) reduction in serum enzymes GOT (ALT), aspartate aminotransferase (AST), GPT alkaline phosphatase (ALP), total bilirubin content and histopathological screening in the rats treated gave indication that ethyl acetate fraction of methanolic extract of Ceiba pentandra possesses hepatoprotective potential against paracetamol-induced hepatotoxicity in rats.
本研究报道了吉贝茎皮甲醇提取物的乙酸乙酯部位对扑热息痛诱导的大鼠肝损伤的保护活性。将乙酸乙酯部位（400mg/kg）口服给予扑热息痛（3g/kg）诱导肝毒性的大鼠。水飞蓟宾（100mg/kg）用作阳性对照。乙酸乙酯部位的高效薄层色谱（HPTLC）指纹图谱显示了其主要化学成分的存在。在接受治疗的大鼠中，血清酶谷草转氨酶（GOT，谷丙转氨酶（ALT）、天冬氨酸转氨酶（AST）、谷丙转氨酶碱性磷酸酶（ALP）、总胆红素含量显著降低（P<0.05），组织病理学检查表明，吉贝甲醇提取物的乙酸乙酯部位对扑热息痛诱导的大鼠肝毒性具有肝保护潜力。
