Kumari Sapna, Goyal Anju, Sönmez Gürer Eda, Algın Yapar Evren, Garg Madhukar, Sood Meenakshi, Sindhu Rakesh K
Chitkara College of Pharmacy, Chitkara University, Rajpura 140401, Punjab, India.
Faculty of Pharmacy, Sivas Cumhuriyet University, 58140 Sivas, Turkey.
Pharmaceutics. 2022 May 19;14(5):1091. doi: 10.3390/pharmaceutics14051091.
Plant-based medicines have received a lot of attention in recent years. Such medicines have been employed to treat medical conditions since ancient times, and in those times only the observed symptoms were used to determine dose accuracy, dose efficacy, and therapy. Rather than novel formulations, the current research work on plant-based medicines has mostly concentrated on medicinal active phytoconstituents. In the past recent decades, however, researchers have made significant progress in developing "new drug delivery systems" (NDDS) to enhance therapeutic efficacy and reduce unwanted effects of bioactive compounds. Nanocapsules, polymer micelles, liposomes, nanogels, phytosomes, nano-emulsions, transferosomes, microspheres, ethosomes, injectable hydrogels, polymeric nanoparticles, dendrimers, and other innovative therapeutic formulations have all been created using bioactive compounds and plant extracts. The novel formulations can improve solubility, therapeutic efficacy, bioavailability, stability, tissue distribution, protection from physical and chemical damage, and prolonged and targeted administration, to name a few. The current study summarizes existing research and the development of new formulations, with a focus on herbal bioactive components.
近年来，植物药受到了广泛关注。自古以来，这类药物就被用于治疗疾病，在那个时候，仅根据观察到的症状来确定剂量准确性、剂量疗效和治疗方法。目前关于植物药的研究工作大多集中在药用活性植物成分上，而非新型制剂。然而，在过去几十年里，研究人员在开发“新型药物递送系统”（NDDS）以提高治疗效果和减少生物活性化合物的不良影响方面取得了重大进展。纳米胶囊、聚合物胶束、脂质体、纳米凝胶、植物体、纳米乳剂、传递体、微球、醇质体、可注射水凝胶、聚合物纳米颗粒、树枝状大分子以及其他创新治疗制剂均已利用生物活性化合物和植物提取物制备而成。这些新型制剂可以改善溶解度、治疗效果、生物利用度、稳定性、组织分布、免受物理和化学损伤以及延长给药时间和实现靶向给药等。本研究总结了现有研究以及新制剂的开发情况，重点关注草药生物活性成分。
