Lampe Renée, Mitternacht Jürgen
Renée Lampe, Center for Cerebral Palsy, and Orthopädische Abteilung des Klinikums rechts der Isar der Technischen Universität;
Orthop Rev (Pavia). 2009 Oct 10;1(2):e20. doi: 10.4081/or.2009.e20.
The field of neuroorthopedics centers on chronic diseases demanding close clinical monitoring. We shall use several examples to show how the various noninvasive diagnostic instruments can be used to obtain insight into the central nervous system as well as into the musculoskeletal system and its morphology. The choice of the most appropriate method depends on the problem; that is, whether the method is to be applied for clinical use or for basic research. In this report we introduce various technical examination methods that are being used successfully in the fields of pediatrics, orthopedics, and neurology. The major examination instrument in pediatric diagnostics is sonography, which is being used in this report as a research instrument for the biomechanics of the musculoskeletal system, but which also gives insight into neurofunctional sequences. In orthopedics, pedography is used for diagnosing deformities of the feet. In neuroorthopedics for children pedography acts as a functional monitor for apraxia and thus allows, for example, a classification of the degree of neurological malfunctions in the lower extremities. The 3D bodyscan is used to minimize x-raying in patients with neurogenic scoliosis. This report introduces examples of the application of MRI and fMRI for basic research. The biometric measuring methods introduced provide precise data in the areas of diagnostics and monitoring and are highly valuable for further neuroorthopedic basic research. In future we expect the ever-evolving technical measuring methods to enable a deeper understanding of the primary neurological causes of and the implications for patients with cerebral palsy and other neuroorthopedic conditions. This may allow the development of new forms of therapy not necessarily predictable today.
神经矫形外科领域主要关注需要密切临床监测的慢性疾病。我们将通过几个例子来说明各种非侵入性诊断仪器如何用于深入了解中枢神经系统以及肌肉骨骼系统及其形态。最合适方法的选择取决于问题所在,即该方法是用于临床还是基础研究。在本报告中,我们介绍了在儿科、矫形外科和神经科领域成功应用的各种技术检查方法。儿科诊断中的主要检查仪器是超声检查,在本报告中它被用作研究肌肉骨骼系统生物力学的仪器,但也能深入了解神经功能序列。在矫形外科中,足部X线摄影用于诊断足部畸形。在儿童神经矫形外科中,足部X线摄影可作为失用症的功能监测手段,例如,可据此对下肢神经功能障碍的程度进行分类。三维全身扫描用于尽量减少神经源性脊柱侧弯患者的X线照射。本报告介绍了磁共振成像(MRI)和功能磁共振成像(fMRI)在基础研究中的应用实例。所介绍的生物测量方法在诊断和监测领域提供了精确数据,对进一步的神经矫形基础研究具有很高价值。未来,我们期望不断发展的技术测量方法能够更深入地了解脑瘫和其他神经矫形疾病患者的原发性神经病因及其影响。这可能会促成如今不一定能预测到的新治疗形式的发展。