Department of Chemistry, Zhengzhou University, Zhengzhou, 450052, P. R. China.
Analyst. 2011 Oct 7;136(19):3943-9. doi: 10.1039/c1an15372b. Epub 2011 Aug 2.
An electrochemical sensor, based on a graphene oxide (GO)-Nafion composite film modified glassy carbon electrode (GCE), was developed and used for detection of trace amounts of colchicine. Owing to the large surface area, good conductivity of GO and good affinity of Nafion, the sensor exhibited excellent electrocatalytic activity for the oxidation of colchicine, displaying a wide linear response from 5.0 × 10(-8) to 2.0 × 10(-5) mol L(-1) and a low detection limit of 1.5 × 10(-8) mol L(-1) in 0.1 mol L(-1) H(2)SO(4) solution. And this modified electrode exhibited a superior immunity from epinephrine, dopamine and ascorbic acid interference. The method was also applied successfully to detect colchicine in medicinal tablets.
一种电化学传感器，基于氧化石墨烯（GO）-Nafion 复合膜修饰玻碳电极（GCE），被开发出来并用于检测微量秋水仙碱。由于 GO 的大表面积、良好的导电性和 Nafion 的良好亲和力，该传感器对秋水仙碱的氧化表现出优异的电催化活性，在 0.1 mol L(-1) H(2)SO(4)溶液中，从 5.0 × 10(-8)到 2.0 × 10(-5) mol L(-1)呈现出宽的线性响应，检测限低至 1.5 × 10(-8) mol L(-1)。并且该修饰电极对肾上腺素、多巴胺和抗坏血酸的干扰具有优异的抗干扰能力。该方法还成功地应用于检测药用片剂中的秋水仙碱。
