多支血管病变患者中金属合金和冠状动脉支架形态的影响。

Influence of metal alloy and the profile of coronary stents in patients with multivessel coronary disease.

机构信息

Hospital Stella Maris, Guarulhos, SP, Brazil.

出版信息

Clinics (Sao Paulo). 2011;66(6):985-9. doi: 10.1590/s1807-59322011000600011.

DOI:10.1590/s1807-59322011000600011

PMID:21808863

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3129974/

Abstract

BACKGROUND

In Brazil, despite the recommendations of the Brazilian Society of Hemodynamics and Interventional Cardiology, the National Health System has not yet approved the use of drug-eluting stents. In percutaneous coronary interventions performed in the public and part of the private health care system, bare metal stents are used as the only option. Therefore, new information on bare metal stents is of great importance. The primary endpoint was to evaluate the influence of the alloy and the profile of coronary stents on late loss and restenosis rates 6 months after implantation in patients with multivessel coronary disease.

METHODS

Single center, randomized and prospective study comparison of cobalt-chromium versus stainless steel stent implantation in 187 patients with multivessel coronary disease. At least one cobalt-chromium and one stainless steel stent were implanted per patient.

RESULTS

Mean age of patients was 59.5 + 10.1 years with a prevalence of males (66.3%) and patients with acute coronary syndrome (56%). Baseline clinical characteristics were similar with hypertension in 146 (78%), dyslipidemia in 85 (45.5%) and diabetes in 68 (36.4%). Two hundred and twenty-nine cobalt-chromium and 284 stainless steel stents were implanted. Angiographic variables showed no statistically significant difference. Angiographic follow-up to 6 months after implantation showed similar late loss and restenosis rates.

CONCLUSION

The use of two different alloys, stainless steel and cobalt-chrome stents, in the same patient and in the same vessel produced similar 6-month restenosis and late loss rates.

摘要

背景

在巴西，尽管巴西血液动力学和介入心脏病学会提出了建议，但国家卫生系统尚未批准使用药物洗脱支架。在公共和部分私人医疗保健系统中进行的经皮冠状动脉介入治疗中，仅使用裸金属支架作为唯一选择。因此，有关裸金属支架的新信息非常重要。主要终点是评估在患有多血管性冠心病的患者中，植入后 6 个月时，合金和冠状动脉支架的类型对晚期损失和再狭窄率的影响。

方法

在 187 例多血管性冠心病患者中进行了单中心，随机和前瞻性研究，比较钴铬与不锈钢支架的植入。每位患者至少植入一个钴铬支架和一个不锈钢支架。

结果

患者的平均年龄为 59.5 + 10.1 岁，男性患病率（66.3％）和急性冠状动脉综合征患者（56％）较高。基线临床特征相似，有 146 例（78％）患有高血压，85 例（45.5％）患有血脂异常和 68 例（36.4％）患有糖尿病。植入了 229 个钴铬支架和 284 个不锈钢支架。血管造影学变量无统计学差异。植入后 6 个月的血管造影随访显示，晚期损失和再狭窄率相似。