Department of Neurobiology and Anatomical Sciences, (formerly the Department of Anatomy), The University of Mississippi Medical Center, Jackson, MS 39216-4505, USA.
Cerebellum. 2011 Sep;10(3):351-5. doi: 10.1007/s12311-011-0304-z.
Prior to the late 1960s, a variety of studies suggested that a general zonal pattern existed within the cerebellar cortex. The hypothesis proposed by Voogd, based on the organization of the subcortical white matter, indicated that this pattern may be very detailed, and he noted that "a further analysis of the corticonuclear projection is still necessary." This brief paper chronicles the approach used by the author to formulate a plan, initiate a large series of experiments (over 250), and follow the sometimes confusing results to finally arrive at an understanding of the details of cerebellar corticonuclear projections. It was discovered that a series of mediolateral cortical zones were present that were topographically related to the underlying cerebellar nuclei, and within each zone, the cortex projected in a rostrocaudal sequence to a specific cerebellar nucleus. The hypothesis proposed by Voogd was fundamentally proven.
在上世纪 60 年代末之前，各种研究表明小脑皮层内存在着一种普遍的分带模式。基于皮质下白质组织的Voogd 假设表明，这种模式可能非常详细，他指出“仍然需要进一步分析皮质核投射。”这篇简短的论文记录了作者用来制定计划、启动一系列大型实验（超过 250 个）并跟踪有时令人困惑的结果的方法，最终对小脑皮质核投射的细节有了了解。发现存在一系列与小脑核有拓扑关系的外侧皮质区，在每个区域内，皮质按照前后顺序投射到特定的小脑核。Voogd 提出的假设得到了根本证明。
