[假鹰爪枝叶的化学成分研究]

[Study on chemical constituents from branches and leaves of Polyalthia nemoralis].

作者信息

Lu Ziming, Zhang Qingjian, Chen Ruoyun, Yu Dequan

机构信息

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2011 Apr;36(8):1024-7.

PMID:21809577

Abstract

OBJECTIVE

To investigate the chemical constituents of the branches and leaves of Polyalthia nemoralis.

METHOD

The compounds were isolated and purified by silica gel, macroporous adsorption resin and Sephadex LH-20 column chromatographic methods. Their chemical structures were elucidated on the basis of physicochemical properties and spectral data.

RESULT

Fourteen compounds were isolated and identified as syringic acid (1), 3-methoxy-4-hydroxycinnamic acid (2), vanillic acid (3), 4-hydroxybenzoic acid (4), mauritianin (5), (+)-xylopinidine (6), (+)-oblongine(7), (+)-tembetarine (8), eythritol (9), D-mannitol (10), ethyl-beta-D-glucopyranoside (11), (+)-magnoflorine (12), stepharanine (13), (2S, 4R)-4-hydroxy-2-piperidine-carboxylic acid (14), respectively.

CONCLUSION

All the compounds were isolated from the genus Polyalthia for the first time; compounds 6 and 13 showed inhibitation activities against multi tumor cell lines.

摘要

目的

研究毛叶暗罗枝叶的化学成分。

方法

采用硅胶柱色谱、大孔吸附树脂柱色谱及Sephadex LH - 20柱色谱法对化合物进行分离纯化，并根据其理化性质和光谱数据确定化学结构。

结果

分离鉴定出14个化合物，分别为丁香酸（1）、3 - 甲氧基 - 4 - 羟基肉桂酸（2）、香草酸（3）、4 - 羟基苯甲酸（4）、毛叶暗罗宁（5）、（+）- 木番荔枝定（6）、（+）- 暗罗碱（7）、（+）- 粉蕊黄杨碱（8）、赤藓醇（9）、D - 甘露醇（10）、β - D - 葡萄糖吡喃苷乙酯（11）、（+）- 木兰花碱（12）、千金藤宁碱（13）、（2S，4R）- 4 - 羟基 - 2 - 哌啶羧酸（14）。