Vahdati Ali, Wagner Diane R
Bioengineering Graduate Program, Aerospace and Mechanical Engineering Department, University of Notre Dame, Notre Dame, IN, USA.
Comput Methods Biomech Biomed Engin. 2012;15(11):1211-21. doi: 10.1080/10255842.2011.585974. Epub 2011 Aug 2.
Most tissue-engineered cartilage constructs are more compliant than native articular cartilage (AC) and are poorly integrated to the surrounding tissue. To investigate the effect of an implanted tissue-engineered construct (TEC) with these inferior properties on the mechanical environment of both the engineered and adjacent native tissues, a finite element study was conducted. Biphasic swelling was used to model tibial cartilage and an implanted TEC with the material properties of either native tissue or a decreased elastic modulus and fixed charged density. Creep loading was applied with a rigid impermeable indenter that represented the femur. In comparison with an intact joint, compressive strains in the transplant, surface contact stress in the adjacent native AC and load partitioning between different phases of cartilage were affected by inferior properties of TEC. Results of this study may lead to a better understanding of the complex mechanical environment of an implanted TEC.
大多数组织工程软骨构建体比天然关节软骨（AC）更具顺应性，并且与周围组织的整合性较差。为了研究具有这些较差特性的植入组织工程构建体（TEC）对工程组织和相邻天然组织的力学环境的影响，进行了一项有限元研究。采用双相肿胀模型模拟胫骨软骨以及具有天然组织材料特性或弹性模量和固定电荷密度降低的植入TEC。使用代表股骨的刚性不透水压头施加蠕变载荷。与完整关节相比，移植体中的压缩应变、相邻天然AC中的表面接触应力以及软骨不同相之间的载荷分配受到TEC较差特性的影响。本研究结果可能有助于更好地理解植入TEC的复杂力学环境。
