通过调节蛋白质稳态实现健康衰老。
Healthy ageing through regulated proteostasis.
机构信息
Institute of Biochemistry II, Goethe University School of Medicine, Frankfurt (Main), Germany.
出版信息
EMBO J. 2011 Aug 3;30(15):2983-5. doi: 10.1038/emboj.2011.237.
EMBO J 30 15, 2990–3003 (2011); published online June 14 2011 During metazoan life, protein homeostasis (proteostasis) declines with age due to impaired proteasome activity. The signalling pathways activated by growth factors that regulate proteostasis and their importance to ageing are just emerging. In this issue, Liu report a crucial role of epidermal growth factor (EGF) in regulating lifespan through the RAF/MAPK pathway. EGF signalling activates the ubiquitin–proteosome system (UPS) and represses the chaperone machinery by modulating the expression of several ageing-related genes (gerontogenes). This strategic switch in controlling global protein turnover provides novel insights into the molecular mechanisms driving ageing in multi-cellular organisms.
EMBO J 30 15, 2990–3003 (2011); published online June 14 2011 在后生动物的生命过程中，由于蛋白酶体活性下降，蛋白质内稳（proteostasis）随年龄增长而衰退。目前刚刚开始出现由生长因子激活的信号通路来调节蛋白质内稳及其对衰老的重要性。在本期杂志中，Liu 报告了表皮生长因子（EGF）通过 RAF/MAPK 途径在调节寿命方面的关键作用。EGF 信号激活泛素-蛋白酶体系统（UPS），通过调节几个与衰老相关的基因（gerontogenes）的表达来抑制伴侣机制。这种控制全局蛋白质周转率的策略转换为驱动多细胞生物衰老的分子机制提供了新的见解。
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