Alcaraz-Contreras Yolanda, Garza-Ocañas Lourdes, Carcaño-Díaz Katya, Ramírez-Gómez Xóchitl Sofía
División de Ciencias Naturales y Exactas, Departamento de Farmacia, Universidad de Guanajuato, Noria Alta s/n, 36050 Guanajuato, Gto., Mexico.
J Toxicol. 2011;2011:430539. doi: 10.1155/2011/430539. Epub 2011 Jul 24.
The effectiveness of glycine in treating experimental lead intoxication was examined in rats. Male Wistar rats were exposed to 3 g/L lead acetate in drinking water for 5 weeks and treated thereafter with glycine (100 and 500 mg/kg, orally) once daily for 5 days or glycine (1000 mg/kg, orally) once daily for 28 days. The effect of these treatments on parameters indicative of oxidative stress (glutathione and malondialdehyde levels), the activity of blood δ-aminolevulinic acid dehydratase, and lead concentration in blood, liver, kidney, brain, and bone were investigated. Liver samples were observed for histopathological changes. Glycine was found to be effective in (1) increasing glutathione levels; (2) reducing malondialdehyde levels; (3) decreasing lead levels in bone with the highest dose. However, glycine had no effect on lead mobilization when 100 and 500 mg/kg glycine were administered. In microscopic examination, glycine showed a protective effect against lead intoxication.
在大鼠中研究了甘氨酸治疗实验性铅中毒的有效性。将雄性Wistar大鼠置于含3 g/L醋酸铅的饮用水中5周，之后分别用甘氨酸（100和500 mg/kg，口服）每日一次，持续5天，或甘氨酸（1000 mg/kg，口服）每日一次，持续28天进行治疗。研究了这些治疗对指示氧化应激的参数（谷胱甘肽和丙二醛水平）、血液δ-氨基乙酰丙酸脱水酶活性以及血液、肝脏、肾脏、大脑和骨骼中铅浓度的影响。观察肝脏样本的组织病理学变化。发现甘氨酸在以下方面有效：（1）提高谷胱甘肽水平；（2）降低丙二醛水平；（3）高剂量时降低骨骼中的铅水平。然而，给予100和500 mg/kg甘氨酸时，甘氨酸对铅的转运没有影响。在显微镜检查中，甘氨酸对铅中毒显示出保护作用。
