School of Studies in Zoology, Jiwaji University, Gwalio, India.
Therapie. 2009 Nov-Dec;64(6):383-8. doi: 10.2515/therapie/2009055. Epub 2009 Dec 23.
The influence of co-administration of zinc (10 mg/kg, intraperitoneal [ip]) and ascorbic acid (10, 20 and 30 mg/kg, ip) against lead (lead acetate; 35 mg/kg, ip for 3 days) induced biochemical alterations was studied in young albino rats. The results revealed significant fall in hemoglobin content, on the other hand significant raise in the activity of serum transaminases and serum alkaline phosphatase after lead administration. Significant increase in lipid peroxidation and decreased level of reduced glutathione in liver showed oxidative stress due to lead exposure. Total protein content in liver and kidney were diminished after lead exposure. Activity of acid phosphatase in liver and kidney and alkaline phosphatase in kidney was increased significantly. Zinc and ascorbic acid treatment showed moderate therapeutic efficacy when administered individually, whereas more pronounced protective effects were observed after combined therapy of zinc and different doses of ascorbic acid. The results thus, suggested that co-administration of zinc and ascorbic acid may be useful in restoration of lead induced biochemical alterations.
本研究旨在探讨锌（10mg/kg，腹腔内注射[ip]）和抗坏血酸（10、20 和 30mg/kg，ip）联合给药对铅（醋酸铅；35mg/kg，ip，连续 3 天）诱导的生化改变的影响。结果表明，铅给药后血红蛋白含量显著下降，而血清转氨酶和血清碱性磷酸酶的活性显著升高。肝脏脂质过氧化增加和还原型谷胱甘肽水平降低表明铅暴露导致氧化应激。铅暴露后肝脏和肾脏中的总蛋白含量减少。肝和肾中的酸性磷酸酶和肾中的碱性磷酸酶活性显著增加。锌和抗坏血酸单独给药时表现出中等的治疗效果，而锌和不同剂量抗坏血酸联合治疗时观察到更明显的保护作用。因此，结果表明，锌和抗坏血酸的联合给药可能有助于恢复铅诱导的生化改变。
