Department of Dermatology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea.
J Eur Acad Dermatol Venereol. 2011 Dec;25(12):1450-4. doi: 10.1111/j.1468-3083.2011.04183.x. Epub 2011 Aug 4.
Female pattern hair loss (FPHL) is the most common cause of hair loss in women, and its prevalence increases with advancing age. Affected women may experience psychological distress and social withdrawal. A variety of laser and light sources have been tried for treatment of hair loss, and some success has been reported.
The purpose of this study was to determine the efficacy and safety of a 1550 nm fractional erbium-glass laser in treatment of female pattern hair loss.
Twenty eight ethnic South Korean patients with varying degrees of FPHL were enrolled in the study. Patients received ten treatments with a 1550 nm fractional Er:Glass Laser (Mosaic, Lutronic Co., Ltd, Seoul, South Korea) at 2-weeks intervals using the same parameters (5-10 mm tip, 6 mJ pulse energy, 800 spot/cm(2) density, static mode). Phototrichogram and global photographs were taken at baseline and at the end of laser treatment, and analysed for changes in hair density and hair shaft diameter. Global photographs underwent blinded review by three independent dermatologists using a 7-point scale. Patients also answered questionnaires assessing hair growth throughout the study. All adverse effects were reported during the study.
Twenty seven patients completed a 5-month schedule of laser treatment. One patient was excluded during treatment due to occurrence of alopecia areata. At the initial visit, mean hair density was 100 ± 14/cm(2) , and mean hair thickness was 58 ± 12 μm. After 5 months of laser treatment, hair density showed a marked increase to 157 ± 28/cm(2) (P < 0.001), and hair thickness also increased to 75 ± 13 μm (P < 0.001). Global photographs showed improvement in 24 (87.5%) of the 27 patients. Two patients (7.4%) reported mild pruritus after laser treatment; however, these resolved within 2 h.
A 1550 nm fractional erbium-glass laser irradiation may be an effective and safe treatment option for women with female pattern hair loss.
女性型脱发（FPHL）是女性脱发最常见的原因，其患病率随着年龄的增长而增加。受影响的女性可能会经历心理困扰和社交退缩。已经尝试了各种激光和光源来治疗脱发，并且已经有一些成功的报道。
本研究旨在确定 1550nm 分数铒玻璃激光治疗女性型脱发的疗效和安全性。
28 名不同程度患有 FPHL 的韩国女性患者参与了这项研究。患者在 2 周的间隔内接受了 10 次 1550nm 分数铒玻璃激光（Mosaic，Lutronic Co.，Ltd.，首尔，韩国）治疗，使用相同的参数（5-10mm 探头，6mJ 脉冲能量，800 点/cm2 密度，静态模式）。在基线和激光治疗结束时拍摄毛发摄影和整体照片，并分析毛发密度和毛发直径的变化。整体照片由三位独立皮肤科医生使用 7 分制进行盲法评估。患者还在整个研究过程中回答了评估头发生长的问卷。在研究期间报告了所有不良反应。
27 名患者完成了 5 个月的激光治疗计划。1 名患者在治疗期间因发生斑秃而被排除。在初次就诊时，平均毛发密度为 100±14/cm2，平均毛发厚度为 58±12μm。经过 5 个月的激光治疗后，毛发密度显著增加至 157±28/cm2（P<0.001），毛发厚度也增加至 75±13μm（P<0.001）。27 名患者中有 24 名（87.5%）的整体照片显示改善。2 名患者（7.4%）在激光治疗后报告有轻度瘙痒，但在 2 小时内缓解。
1550nm 分数铒玻璃激光照射可能是治疗女性型脱发的有效且安全的选择。
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