Meephansan Jitlada, Ungpraphakorn Nawaporn, Ponnikorn Saranyoo, Suchonwanit Poonkiat, Poovorawan Yong
Division of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand.
Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand.
Dermatol Surg. 2018 Oct;44(10):1295-1303. doi: 10.1097/DSS.0000000000001619.
A new treatment for androgenetic alopecia (AGA) is a 1,550-nm erbium-glass (Er:Glass) fractional laser. The wound healing process associated with this treatment is believed to be due to the stimulation of hair regrowth. Both the Wingless-related integration site (Wnt) proteins and insulin-like growth factor 1 (IGF-1) are important molecules that promote new hair growth.
The aim of this study was to evaluate the efficacy of 1,550-nm Er:Glass fractional laser treatment and determine the gene expression of IGF-1 and Wnt/β-catenin in patients with AGA.
Twenty-three patients with AGA were enrolled. They received 12 treatments at 2-week intervals. A scalp biopsy was performed to evaluate mRNA levels of Wnt10A and IGF-1. Histopathologic samples were collected.
Significant increases in hair count and shaft diameter that occurred from Month 4 until the end of the study were observed. Histological results showed increases in the follicular unit, anagen hair count, and the anagen:telogen ratio. No up-regulation of Wnt10A and IGF-1 mRNA was observed.
The 1,550-nm Er:Glass fractional laser treatment can increase hair density and shaft diameter in patients with AGA. The mechanisms by which 1,550-nm Er:Glass laser treatment induces new hair growth may not be limited to Wnt10A/β-catenin or IGF-1 expression.
一种用于治疗雄激素性脱发（AGA）的新方法是使用1550纳米铒玻璃（Er:Glass）分数激光。据信，与这种治疗相关的伤口愈合过程是由于刺激了头发生长。无翅相关整合位点（Wnt）蛋白和胰岛素样生长因子1（IGF-1）都是促进新头发生长的重要分子。
本研究的目的是评估1550纳米Er:Glass分数激光治疗的疗效，并确定AGA患者中IGF-1和Wnt/β-连环蛋白的基因表达。
招募了23名AGA患者。他们每隔2周接受12次治疗。进行头皮活检以评估Wnt10A和IGF-1的mRNA水平。收集组织病理学样本。
观察到从第4个月到研究结束时头发数量和发干直径显著增加。组织学结果显示毛囊单位、生长期毛发数量和生长期与休止期比例增加。未观察到Wnt10A和IGF-1 mRNA上调。
1550纳米Er:Glass分数激光治疗可增加AGA患者的头发密度和发干直径。1550纳米Er:Glass激光治疗诱导新头发生长的机制可能不限于Wnt10A/β-连环蛋白或IGF-1表达。
