Lowery M C, Au W W, Adams P M, Whorton E B, Legator M S
Department of Pathology, Penrose Pathology Group, Colorado Springs, CO 80907-7699.
Mutat Res. 1990 Apr;229(2):213-29. doi: 10.1016/0027-5107(90)90095-l.
The assessment of behavioral development in the progeny of males exposed to known mutagenic chemicals is a potentially sensitive endpoint for detecting transmissible abnormalities. A genetic component is demonstrated as these behavioral abnormalities can also be passed on to the F2 generation. In this review, experimental studies exploring transmission of behavioral deficits from paternal exposure to drugs, chemicals and radiation are addressed. Additionally included is a brief synopsis of recent work performed in our laboratory investigating such abnormalities in offspring from male rats exposed to ionizing radiations. The implications of these behavioral endpoints to humans is also discussed.
对接触已知诱变化学物质的雄性后代的行为发育进行评估，是检测可传播异常的一个潜在敏感指标。由于这些行为异常也能遗传给F2代，因此证明了其遗传成分。在这篇综述中，探讨了从父系接触药物、化学物质和辐射导致行为缺陷传递的实验研究。此外，还简要概述了我们实验室最近开展的工作，该工作研究了暴露于电离辐射的雄性大鼠后代中的此类异常情况。还讨论了这些行为指标对人类的影响。
