Armah G E, Nishikawa S, Miki S, Omata Y, Nakabayashi T, Tomita K
Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Mol Biochem Parasitol. 1990 Jan 1;38(1):135-40. doi: 10.1016/0166-6851(90)90213-6.
Peptide vaccines based on units of the immunodominant tetrapeptide repeats, Asn-Ala-Asn-Pro and Asn-Val-Asp-Pro, of the circumsporozoite surface protein of the parasite Plasmodium falciparum are presently being developed as potential malaria vaccines. The N-terminal fusion of a hydrophobic protein to units of the tetrapeptide repeat affected the immunogenicity and conformational stability of the peptide, and also induced a secondary structure in the peptide. Peptide antigenicity, as well as conformational stability, was significantly increased.
