Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Ferrara and Azienda Ospedaliero-Universitaria S. Anna, Ferrara, Italy.
Lupus. 2011 Oct;20(12):1305-11. doi: 10.1177/0961203311409610. Epub 2011 Aug 3.
To assess the outcome of pregnancy and disease flare or differentiation into well-defined connective tissue disease (CTD), in a cohort of pregnant patients with undifferentiated connective tissue disease (UCTD) and to compare these findings with those obtained from a population of non-pregnant women with UCTD.
In total, 55 pregnancies (in 50 UCTD patients) were monitored from the positive pregnancy test until the sixth month after delivery. Likewise, during a 15-month timeframe, the incidence of flares or evolution into a major CTD was also recorded in a population of 53 non-pregnant women with UCTD. The Student t-test was applied for unpaired, continuous variables and chi-square was applied when percentages were compared.
The mean duration of the successful pregnancies was 38.6 weeks (range 28-42) while the mean birth weight was 3190 g (range 1200-4600 g). Three pregnancies (5.4%) ended in miscarriage. The following obstetric complications were found: five premature membrane ruptures, two preeclampsia and two intra-uterine growth restrictions. In a total of 16 patients (32%) the disease flared during pregnancy or during the 6-month post-delivery period. Of these, five developed well-defined CTD after delivery. In the control population, six patients flared (11%) and, of these, only one developed a well-defined CTD.
If pregnancy is properly treated, the outcome in UCTD patients is generally good while, considering disease activity, pregnancy appears to be a clear risk factor for flare up or evolution into well-defined CTD.
评估未分化结缔组织病（UCTD）妊娠患者的妊娠结局和疾病活动或分化为明确结缔组织病（CTD）的情况，并将这些发现与非妊娠UCTD 患者的情况进行比较。
共监测了 55 例妊娠（50 例 UCTD 患者），从妊娠试验阳性开始至分娩后 6 个月。同样，在 15 个月的时间内，还记录了 53 例非妊娠 UCTD 患者中疾病活动或演变为主要 CTD 的发生率。采用配对、连续变量的学生 t 检验和比较百分比的卡方检验。
成功妊娠的平均持续时间为 38.6 周（范围 28-42 周），平均出生体重为 3190 克（范围 1200-4600 克）。三例妊娠（5.4%）流产。发现以下产科并发症：五例胎膜早破、两例子痫前期和两例宫内生长受限。共有 16 例患者（32%）在妊娠期间或分娩后 6 个月内疾病活动。其中，五例产后发展为明确的 CTD。在对照组中，六例患者病情活动（11%），其中仅一例发展为明确的 CTD。
如果妊娠得到适当治疗，UCTD 患者的预后通常良好，而考虑到疾病活动，妊娠似乎是疾病活动或演变为明确 CTD 的明显危险因素。
