Rapini R P
Department of Dermatology, University of Texas Medical School, Houston.
Prim Care. 1990 Mar;17(1):127-44.
Clinically visible venereal warts are only one manifestation of the much larger problem of HPV infection, which may be the most common venereal disease if subclinical infections are considered. HPV infection probably is undiagnosed in at least 80% of cases because subclinical infection can be identified only by acetic acid application, magnification, Pap smears, or molecular DNA hybridization techniques applied to cytology or biopsy specimens. Genital HPV is present in up to 35% of some populations and in 6-11% of both men and women with clinically normal genitalia. Patients and their sexual partners should be monitored for cervical carcinoma and other epithelial malignancies associated with HPV infection. Although visible lesions can often be eradicated with the many available therapies, it is unlikely that all HPV can be destroyed where it has been incorporated into the DNA of clinically normal epithelium. Therefore, excessively vigorous, painful therapy is probably unwarranted.
临床上可见的尖锐湿疣只是人乳头瘤病毒（HPV）感染这一更大问题的一种表现，如果将亚临床感染考虑在内，HPV感染可能是最常见的性传播疾病。HPV感染在至少80%的病例中可能未被诊断出来，因为亚临床感染只能通过涂抹醋酸、放大观察、巴氏涂片或应用于细胞学或活检标本的分子DNA杂交技术来识别。在某些人群中，高达35%的人存在生殖器HPV感染，在生殖器外观正常的男性和女性中，这一比例为6%-11%。应对患者及其性伴侣进行监测，以筛查与HPV感染相关的宫颈癌和其他上皮恶性肿瘤。尽管现有的多种治疗方法通常可以根除可见病变，但在HPV已整合到临床正常上皮细胞DNA中的情况下，不太可能将所有HPV都清除。因此，过度积极、带来痛苦的治疗可能是不必要的。
