Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Int J Neurosci. 2011 Dec;121(12):684-90. doi: 10.3109/00207454.2011.610529. Epub 2011 Sep 12.
CD24 is a glycosylphosphatidylinositol (GPI)-linked cell surface glycoprotein expressed in central nervous system cells. Recent investigations have suggested that CD24 participates in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). However, a limited number of studies have been published regarding the contribution of CD24 to the risk and severity of MS in humans. We investigated the contribution of a CD24 single nucleotide polymorphism (SNP) to MS disease risk and severity. We also studied mRNA expression of the CD24 gene in Iranian MS patients using quantitative real-time polymerase chain reaction (PCR). Our findings showed that the CD24(v/v) genotype was significantly more frequent in MS patients compared with controls (p(c) = .004). Moreover, a statistically significant difference in the Multiple Sclerosis Severity Score (MSSS) was found between MS patients carrying CD24(a/a) and CD24(v/v) genotypes (p = .008). The results also indicated that the expression of CD24 mRNA was 1.7 times more in MS patients compared with controls. In conclusion, our results suggest that the CD24(v/v) genotype influences both MS disease risk and severity in Iranian MS patients, and the high disease severity in CD24(v/v) patients may indicate that they require more aggressive treatment than do patients carrying CD24(a/a).
CD24 是一种糖基磷脂酰肌醇 (GPI) 连接的细胞表面糖蛋白，在中枢神经系统细胞中表达。最近的研究表明，CD24 参与实验性自身免疫性脑脊髓炎 (EAE) 的发病机制，EAE 是多发性硬化症 (MS) 的动物模型。然而，关于 CD24 对人类 MS 风险和严重程度的贡献，发表的研究数量有限。我们研究了 CD24 单核苷酸多态性 (SNP) 对 MS 疾病风险和严重程度的贡献。我们还使用定量实时聚合酶链反应 (PCR) 研究了伊朗 MS 患者中 CD24 基因的 mRNA 表达。我们的研究结果表明，与对照组相比，MS 患者的 CD24(v/v) 基因型明显更为常见 (p(c) =.004)。此外，携带 CD24(a/a) 和 CD24(v/v) 基因型的 MS 患者之间的多发性硬化严重程度评分 (MSSS) 存在统计学显著差异 (p =.008)。结果还表明，与对照组相比，MS 患者的 CD24 mRNA 表达增加了 1.7 倍。总之，我们的研究结果表明，CD24(v/v) 基因型既影响伊朗 MS 患者的 MS 疾病风险，也影响疾病严重程度，而 CD24(v/v) 患者的高疾病严重程度可能表明他们需要比携带 CD24(a/a) 的患者更积极的治疗。
