CD24 Ala/Val基因多态性与多发性硬化症风险之间的关联：一项荟萃分析。
Association between CD24 Ala/Val polymorphism and multiple sclerosis risk: A meta analysis.
作者信息
Yang Wan, Zhou Wang, Zhang Bo-Kang, Kong Ling-Suo, Zhu Xing-Xing, Wang Rui-Xiang, Yang Yue, Chen Yun-Fei, Chen Lan-Ren
机构信息
Department of Anesthesiology, Anhui Provincial Cancer Hospital, Hefei.
Department of Anesthesiology, West District of Anhui Provincial Hospital, Hefei.
出版信息
Medicine (Baltimore). 2020 Apr;99(15):e19530. doi: 10.1097/MD.0000000000019530.
BACKGROUND
The aim of this study was to explore the association between CD24 Ala/Val polymorphism and susceptibility of multiple sclerosis (MS).
METHODS
A comprehensive literature search for relevant studies was performed on google scholar, PubMed, Web of science, Embase, the Chinese National Knowledge Infrastructure and the Chinese Biology Medicine. This meta-analysis was conducted using the STATA 11.0 software and the pooled odds ratio with 95% confidence interval was calculated.
RESULTS
Seven case-control studies were included in this meta-analysis. The results showed significant association between CD24 Ala/Val polymorphism and susceptibility to MS. Stratified analysis by areas also showed significant association in Asians. However, no association was found in Europeans.
CONCLUSION
This study suggested that the CD24 Val allele was associated with an increased risk of MS and larger-scale studies of populations are needed to explore the role of CD24 Ala/Val polymorphism during the pathogenesis of MS.
背景
本研究旨在探讨CD24 Ala/Val多态性与多发性硬化症（MS）易感性之间的关联。
方法
在谷歌学术、PubMed、科学网、Embase、中国知网和中国生物医学数据库中对相关研究进行全面的文献检索。使用STATA 11.0软件进行这项荟萃分析，并计算合并比值比及95%置信区间。
结果
本荟萃分析纳入了7项病例对照研究。结果显示CD24 Ala/Val多态性与MS易感性之间存在显著关联。按地区进行的分层分析在亚洲人群中也显示出显著关联。然而，在欧洲人群中未发现关联。
结论
本研究表明CD24 Val等位基因与MS风险增加相关，需要开展更大规模的人群研究以探讨CD24 Ala/Val多态性在MS发病机制中的作用。
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