Ripoptosome：细胞质中的死亡决定。
The Ripoptosome: death decision in the cytosol.
机构信息
Molecular Signaling and Cell Death Unit, Department for Molecular Biomedical Research, VIB, Ghent, Belgium.
出版信息
Mol Cell. 2011 Aug 5;43(3):323-5. doi: 10.1016/j.molcel.2011.07.007.
PMID:21816342
Abstract
In this issue of Molecular Cell, Tenev et al. and Feoktistova et al. describe the Ripoptosome, a cytosolic death-inducing RIP1-, FADD-, and caspase-8-containing complex that spontaneously assembles upon cIAP depletion, challenging the view that such complexes exclusively originate from receptor activation.
摘要
在本期《分子细胞》中，Tenev 等人和 Feoktistova 等人描述了 Ripoptosome，这是一种含有细胞质死亡诱导的 RIP1、FADD 和 caspase-8 的复合物，在 cIAP 耗竭时会自发组装，这挑战了这样的复合物仅源自受体激活的观点。
Zotero 插件