Azhayev A V, Ozols A M, Bushnev A S, Dyatkina N B, Kochetkova S V, Victorova L S, Kukhanova M K, Krayevsky A A, Gottikh B P
Nucleic Acids Res. 1979 Feb;6(2):625-43. doi: 10.1093/nar/6.2.625.
A new procedure has been developed for the synthesis of 3'-amino-3'-deoxyribonucleosides of adenine, cytosine and uracil by condensing the trimethylsilylated bases with peracylated 3-azido-3-deoxyribose derivative. The azido group could subsequently be reduced to amino. The 5'-phosphates of these nucleosides have been prepared and the analogues have been tested for their ability to stimulate the ribosome-catalyzed reaction of 3'(2')-O-(N-formylmethionyl) adenosine 5'-phosphate with phenylalanyl-tRNA.
通过将三甲基硅烷基化碱基与全酰化的3-叠氮基-3-脱氧核糖衍生物缩合，已开发出一种合成腺嘌呤、胞嘧啶和尿嘧啶的3'-氨基-3'-脱氧核糖核苷的新方法。叠氮基随后可被还原为氨基。已制备了这些核苷的5'-磷酸酯，并测试了这些类似物刺激核糖体催化的3'(2')-O-(N-甲酰甲硫氨酰)腺苷5'-磷酸与苯丙氨酰-tRNA反应的能力。
