Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA 95064, USA.
J Mammary Gland Biol Neoplasia. 2011 Sep;16(3):257-70. doi: 10.1007/s10911-011-9225-1. Epub 2011 Aug 5.
Slit, Netrin, Ephrin, and Semaphorin's roles in development have expanded greatly in the past decade from their original characterization as axon guidance molecules (AGMs) to include roles as regulators of tissue morphogenesis and development in diverse organs. In the mammary gland, AGMs are important for maintaining normal cell proliferation and adhesion during development. The frequent dysregulation of AGM expression during tumorigenesis and tumor progression suggests that AGMs also play a crucial role as tumor suppressors and oncogenes in breast cancer. Moreover, these findings suggest that AGMs may be excellent targets for new breast cancer prognostic tests and more effective therapeutic strategies.
在过去的十年中，Slit、Netrin、Ephrin 和 Semaphorin 的作用已经大大扩展，从最初作为轴突导向分子（AGMs）的特征，扩展到在不同器官中作为组织形态发生和发育的调节剂。在乳腺中，AGMs 对于维持发育过程中正常的细胞增殖和黏附非常重要。在肿瘤发生和肿瘤进展过程中，AGM 的表达经常失调，这表明 AGMs 也作为乳腺癌的肿瘤抑制因子和癌基因发挥着关键作用。此外，这些发现表明，AGMs 可能是新的乳腺癌预后测试和更有效的治疗策略的优秀靶点。
