Division of Biomedical Sciences, Edward via College of Osteopathic Medicine, Virginia Tech Corporate Research Center, Blacksburg, VA 24060, USA.
Cardiovasc Toxicol. 2012 Mar;12(1):39-45. doi: 10.1007/s12012-011-9136-9.
NAD(P)H: quinone oxidoreductase (NQO) represents a family of flavoproteins that catalyze the two-electron reduction of quinones and their derivatives. In mammalian systems, there are two members of NQO, namely, NQO1 and NQO2. NQO1 utilizes NAD(P)H, whereas NQO2 employs dihydronicotinamide riboside (NRH) as the electron donors. In addition to the well-documented action in reducing quinone compounds and preventing the formation of reactive oxygen species, NQO enzymes, especially NQO1 also possess other important biological activities. These include anti-inflammatory effects, direct scavenging of superoxide anion radicals, and stabilization of p53 and other tumor suppressors. Recently, multiple studies in animal models demonstrated a potential role for NQO1 in protecting against cardiovascular injury and related conditions, including atherogenesis, dyslipidemia, and insulin resistance. Functional gene polymorphisms have been identified in human NQO1 gene. Studies on the association between NQO1 gene polymorphisms and susceptibility to disease development also suggested a possible involvement of NQO1 in human cardiovascular diseases and metabolic syndrome. This review is intended to summarize the recent development regarding the biochemical properties and molecular regulation of NQO1 and its potential beneficial role in cardiovascular diseases and related conditions, including metabolic syndrome.
NAD(P)H：醌氧化还原酶 (NQO) 代表一类黄素蛋白，可催化醌及其衍生物的两电子还原。在哺乳动物系统中，有两种 NQO 成员，即 NQO1 和 NQO2。NQO1 利用 NAD(P)H，而 NQO2 则利用二氢烟酰胺核糖 (NRH) 作为电子供体。除了在还原醌类化合物和防止活性氧形成方面的作用已得到充分证实外，NQO 酶，尤其是 NQO1，还具有其他重要的生物学活性。这些活性包括抗炎作用、直接清除超氧阴离子自由基以及稳定 p53 和其他肿瘤抑制因子。最近，动物模型中的多项研究表明，NQO1 在保护心血管免受损伤和相关疾病方面具有潜在作用，包括动脉粥样硬化、血脂异常和胰岛素抵抗。在人类 NQO1 基因中已鉴定出功能性基因多态性。关于 NQO1 基因多态性与疾病易感性之间关联的研究也表明，NQO1 可能参与了人类心血管疾病和代谢综合征。本综述旨在总结 NQO1 的生化特性和分子调控及其在心血管疾病和相关疾病（包括代谢综合征）中的潜在有益作用的最新进展。
