Slepushkin V D
Probl Endokrinol (Mosk). 1979 Mar-Apr;25(2):51-4.
Experiments on dogs demonstrated that intravenous administration of the epiphysis extracts prevented the antidiuretic action of both the endogenous (traumatic stress) and exogenous (pituitrin) antidiuretic hormone (ADH). Injection of the extract into the renal artery gave a unilateral diuretic effect. The diuretic action of the preparation was eliminated by the block of the alpha-adrenergic receptors, whereas beta-adrenoblockers were ineffective. A conclusion was drawn that the mechanism of the diuretic action of the epiphysis extracts consisted in the competitive suppression of the ADH action at the renal tubules level on account of excitation of the alpha-adrenoceptors and inhibition of the adenylcyclase activity.
对狗的实验表明，静脉注射松果体提取物可抑制内源性（创伤应激）和外源性（垂体后叶素）抗利尿激素（ADH）的抗利尿作用。将提取物注入肾动脉可产生单侧利尿作用。该制剂的利尿作用可通过阻断α-肾上腺素能受体而消除，而β-肾上腺素能阻滞剂则无效。得出的结论是，松果体提取物的利尿作用机制在于，由于α-肾上腺素能受体的兴奋和腺苷酸环化酶活性的抑制，在肾小管水平竞争性抑制ADH的作用。
