Poole Leslie B, Hall Andrea, Nelson Kimberly J
Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Curr Protoc Toxicol. 2011 Aug;Chapter 7:Unit7.9. doi: 10.1002/0471140856.tx0709s49.
Peroxiredoxins are important hydroperoxide detoxification enzymes, yet have only come to the fore in recent years relative to the other major players in peroxide detoxification, heme-containing catalases and peroxidases and glutathione peroxidases. These cysteine-dependent peroxidases exhibit high reactivity with hydrogen peroxide, organic hydroperoxides, and peroxynitrite and play major roles not only in peroxide defense, but also in regulating peroxide-mediated cell signaling. This overview focuses on important peroxiredoxin features that have emerged over the past several decades with an emphasis on catalytic mechanism, regulation, and biological function.
过氧化物酶是重要的氢过氧化物解毒酶，但相对于过氧化物解毒的其他主要参与者，含血红素的过氧化氢酶、过氧化物酶和谷胱甘肽过氧化物酶而言，它们直到近年来才受到关注。这些依赖半胱氨酸的过氧化物酶对过氧化氢、有机氢过氧化物和过氧亚硝酸根具有高反应活性，不仅在过氧化物防御中起主要作用，还在调节过氧化物介导的细胞信号传导中发挥重要作用。本综述重点介绍了过去几十年中出现的过氧化物酶的重要特性，重点是催化机制、调节和生物学功能。
