Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin, China.
Macromol Biosci. 2011 Nov 10;11(11):1499-504. doi: 10.1002/mabi.201100196. Epub 2011 Aug 4.
Random and diblock copolymers of 2-(N,N-dimethylamino)ethyl methacrylate and butyl methacrylate are prepared by ATRP. As mimics of cationic antimicrobial peptides, the random and diblock copolymers show similar antimicrobial activities. In contrast, the diblock copolymers have much lower hemolytic activities than the random copolymers. The cell selectivity (HC(50)/MIC, where HC(50) is the concentration to lyse 50% of human red blood cells and MIC is the minimum concentration to inhibit bacterial growth) of the diblock copolymers are 150 to 27,500 times higher than that of random copolymers with similar compositions.
通过原子转移自由基聚合（ATRP）制备了 2-（N，N-二甲基氨基）乙基甲基丙烯酸酯和甲基丙烯酸丁酯的无规和嵌段共聚物。作为阳离子抗菌肽的模拟物，无规和嵌段共聚物表现出相似的抗菌活性。相比之下，嵌段共聚物的溶血活性远低于无规共聚物。嵌段共聚物的细胞选择性（HC（50）/MIC，其中 HC（50）是裂解 50%人红细胞的浓度，MIC 是抑制细菌生长的最小浓度）比具有相似组成的无规共聚物高 150 至 27,500 倍。
