Instituto de Ciencia y Tecnología de Polímeros (ICTP-CSIC), Juan de la Cierva 3, 28006 Madrid, Spain.
Biomacromolecules. 2015 Jan 12;16(1):295-303. doi: 10.1021/bm5014876. Epub 2014 Dec 10.
Polymers with quaternary ammonium groups such as quaternized poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMAQ) have been used as antimicrobial agents because of their demonstrated good antimicrobial activities against a huge number and types of microbes, although their cytotoxicity is also well-known. In this work block copolymers based on PDMAEMAQ were synthesized containing hydrophobic segments of poly(butyl methacrylate) to improve the antimicrobial activity and glycomonomer units with the aim of decreasing the cytotoxicity of the polymers. Hydrophobic butyl methacrylate (BMA) blocks were chain extended by statistical and block copolymers of DMAEMA and 2-{[(d-glucosamin-2-N-yl)carbonylethyl methacrylate (HEMAGl) glycomonomer of different compositions. In order to find the balance between antimicrobial activity and cytotoxicity, the selectivity index of each polymer was obtained from minimum inhibitory concentrations (MIC) and white and red blood cells toxicity measurements.
具有季铵基团的聚合物，如季铵化聚（2-（二甲氨基）乙基甲基丙烯酸酯）（PDMAEMAQ），由于其对大量和多种微生物表现出良好的抗菌活性，已被用作抗菌剂，尽管它们的细胞毒性也众所周知。在这项工作中，合成了基于 PDMAEMAQ 的嵌段共聚物，其中含有疏水性聚（甲基丙烯酸丁酯）段，以提高抗菌活性，并含有糖单体单元，旨在降低聚合物的细胞毒性。疏水性丁基甲基丙烯酸酯（BMA）块通过统计和嵌段共聚物的 DMAEMA 和 2-（[（D-葡糖胺-2-N-基）羰基乙基甲基丙烯酸酯（HEMAGl）糖单体的不同组成进行链扩展。为了在抗菌活性和细胞毒性之间找到平衡，从最小抑菌浓度（MIC）和白细胞和红细胞毒性测量中获得了每种聚合物的选择性指数。
