Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil.
Oral Dis. 2011 Nov;17(8):808-12. doi: 10.1111/j.1601-0825.2011.01841.x. Epub 2011 Aug 8.
The aim of this study was to determine the expression of fatty acid synthase (FASN) in oral nevi and melanomas, comparing the results with correspondent cutaneous lesions.
Expression of FASN was evaluated by immunohistochemistry in 51 oral melanocytic lesions, including 38 intramucosal nevi and 13 primary oral melanomas, in 10 cutaneous nevi and in 14 melanomas.
Fatty acid synthase was strongly expressed only in melanomas, either of the oral mucosa or cutaneous. On the other hand, most oral and cutaneous nevi were negative, with a few oral cases showing focal and weak expression.
Fatty acid synthase is expressed in malignant melanocytes, and it can be a helpful marker to distinguish oral melanomas from oral melanocytic nevi.
本研究旨在确定脂肪酸合酶（FASN）在口腔痣和黑色素瘤中的表达情况，并将结果与相应的皮肤病变进行比较。
通过免疫组织化学方法检测 51 例口腔黑素细胞病变（包括 38 例黏膜内痣和 13 例原发性口腔黑色素瘤）、10 例皮肤痣和 14 例黑色素瘤中 FASN 的表达情况。
FASN 仅在口腔黏膜或皮肤的黑色素瘤中强烈表达。另一方面，大多数口腔和皮肤痣均为阴性，少数口腔痣呈局灶性和弱阳性表达。
脂肪酸合酶在恶性黑素细胞中表达，可作为区分口腔黑色素瘤与口腔黑素细胞痣的有用标志物。
