de Souza do Nascimento Juliana, Carlos Román, Delgado-Azañero Wilson, Mosqueda Taylor Adalberto, de Almeida Oslei Paes, Romañach Mário José, de Andrade Bruno Augusto Benevenuto
School of Dentistry, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil.
Pathology Section, Centro Clínico de Cabeza y Cuello/Hospital Herrera Llerandi, Guatemala City, Guatemala.
J Oral Pathol Med. 2016 Jul;45(6):440-3. doi: 10.1111/jop.12385. Epub 2015 Nov 26.
Cyclooxygenase-2 (COX-2) catalyses the conversion of arachidonic acid to prostaglandin, and its overexpression has been demonstrated in different malignant tumors, including cutaneous melanoma. However, no data about the expression of this protein in oral melanocytic lesions are available to date. The aim of this study was to evaluate the immunohistochemical expression of COX-2 in oral nevi and melanomas, comparing the results with correspondent cutaneous lesions.
COX-2 was evaluated by immunohistochemistry in 49 oral melanocytic lesions, including 36 intramucosal nevi and 13 primary oral melanomas, and in four cutaneous nevi and eight melanomas.
All cases of oral and cutaneous melanomas were positive for COX-2. On the other hand, all oral and cutaneous melanocytic nevi were negative.
COX-2 is highly positive in oral melanomas and negative in oral nevi and might represent a useful marker to distinguish melanocytic lesions of the oral cavity.
环氧合酶-2（COX-2）催化花生四烯酸转化为前列腺素，其在包括皮肤黑色素瘤在内的不同恶性肿瘤中均有过表达。然而，目前尚无关于该蛋白在口腔黑素细胞性病变中表达情况的数据。本研究旨在评估COX-2在口腔痣和黑色素瘤中的免疫组化表达，并将结果与相应的皮肤病变进行比较。
采用免疫组化法对49例口腔黑素细胞性病变进行COX-2评估，其中包括36例黏膜内痣和13例原发性口腔黑色素瘤，以及4例皮肤痣和8例黑色素瘤。
所有口腔和皮肤黑色素瘤病例的COX-2均呈阳性。另一方面，所有口腔和皮肤黑素细胞痣均为阴性。
COX-2在口腔黑色素瘤中高度阳性，在口腔痣中为阴性，可能是区分口腔黑素细胞性病变的有用标志物。
