肢端肥大症与妊娠。

Acromegaly and pregnancy.

机构信息

Pôle cardiovasculaire et métabolique, service d'endocrinologie, maladies métaboliques et nutrition, CHU Rangueil-Larrey, 24, chemin de Pouvourville, TSA 30030, 31059 Toulouse cedex 9, France.

出版信息

Ann Endocrinol (Paris). 2011 Sep;72(4):282-286. doi: 10.1016/j.ando.2011.07.002. Epub 2011 Aug 4.

DOI:10.1016/j.ando.2011.07.002

PMID:21820101

Abstract

In women with acromegaly due to growth hormone (GH)-secreting pituitary adenomas, the occurrence of pregnancy warrants consideration of: (1) the consequences of pregnancy on the pituitary adenoma including the tumor syndrome and GH/IGF-1 secretion, (2) the consequence of GH/IGF-1 hypersecretion on the pregnant woman and the fetus, (3) the consequences of pituitary surgery and medical treatment (dopamine agonists, somatostatin analogs, GH receptor antagonist) on the pregnant woman and the developing fetus.

摘要

在因生长激素（GH）分泌垂体腺瘤而患有肢端肥大症的女性中，妊娠的发生需要考虑以下几点：（1）妊娠对垂体腺瘤的影响，包括肿瘤综合征和 GH/IGF-1 分泌；（2）GH/IGF-1 过度分泌对孕妇和胎儿的影响；（3）垂体手术和药物治疗（多巴胺激动剂、生长抑素类似物、GH 受体拮抗剂）对孕妇和发育中胎儿的影响。