Department of Exercise and Movement Science, University of Vermont, Burlington, VT 05405-0068, USA.
Metabolism. 2012 Feb;61(2):237-41. doi: 10.1016/j.metabol.2011.06.019. Epub 2011 Aug 4.
Two recent examinations reported a strong association between blood pressure (BP) and resting energy expenditure (REE), independent of body mass and body composition. Both reports postulate that neurohumoral processes that contribute to variation in REE may partly mediate the body mass effect on BP. Therefore, we examined the relationship of REE and BP in 108 asymptomatic women (a) to confirm previous findings in a novel population and (b) to examine the impact of a marker of sympathetic tone on this relationship, as this was indicated as a potentially salient intermediary in previous reports. All testing was performed during a 4-day admission to the General Clinical Research Center. Resting energy expenditure was measured by indirect calorimetry, body composition was determined by dual-energy x-ray absorptiometry, and 24-hour fractionated urinary norepinephrine was determined by high-performance liquid chromatography. Multiple linear regression revealed REE as a significant predictor of systolic BP (β = 0.30, P = .04), independent of race (β = 0. 28, P = .01), age (β = -0.02, P = .80), height (β = -0.38, P = .08), fat mass (β = 0.22, P = .20), fat-free mass (β = 0.08, P = .65), and 24-hour fractionated urinary norepinephrine (β = 0.06, P = .57); and the same model using diastolic BP as the dependent variable approached significance (β = 0.24, P = .09). This study affirms previous findings that REE may be a potential mediator in resting BP, independent of many well-cited factors and, additionally, a marker of sympathetic tone.
两项最近的研究报告显示，血压（BP）与静息能量消耗（REE）之间存在很强的关联，而不受体重和身体成分的影响。这两项研究报告都提出，导致 REE 变化的神经激素过程可能部分介导了体重对 BP 的影响。因此，我们在 108 名无症状女性中检查了 REE 与 BP 的关系，（a）在一个新的人群中证实了之前的发现，（b）检查了交感神经张力标志物对这种关系的影响，因为这在前述报告中被认为是一个潜在的重要中介。所有测试都是在 4 天的住院期间在综合临床研究中心进行的。通过间接热量测定法测量静息能量消耗，通过双能 X 射线吸收测定法确定身体成分，通过高效液相色谱法测定 24 小时分段尿去甲肾上腺素。多元线性回归显示，REE 是收缩压的一个显著预测因子（β=0.30，P=0.04），与种族（β=0.28，P=0.01）、年龄（β=-0.02，P=0.80）、身高（β=-0.38，P=0.08）、体脂量（β=0.22，P=0.20）、去脂体重（β=0.08，P=0.65）和 24 小时分段尿去甲肾上腺素（β=0.06，P=0.57）无关；而使用舒张压作为因变量的相同模型接近显著（β=0.24，P=0.09）。这项研究证实了之前的发现，即 REE 可能是静息 BP 的一个潜在中介，而不受许多公认的因素的影响，此外，REE 还是交感神经张力的标志物。
