Pozos-Guillen Amaury, Martinez-Rider Ricardo, Aguirre-Banuelos Patricia, Perez-Urizar Jose
Department of Oral and Maxillofacial Surgery, Facultad de Estomatología, Universidad Autonoma de San Luis Potosi, San Luis Potosi, Mexico.
J Oral Maxillofac Surg. 2007 Jul;65(7):1315-20. doi: 10.1016/j.joms.2006.10.079.
We compared the efficacy of tramadol given before or immediately after surgical extraction of an impacted mandibular third molar under local anesthesia.
In this prospective, randomized, controlled, double-blind pilot study, 3 groups of 20 patients each were included: tramadol preoperative, 100 mg intramuscularly (IM) 1 hour before surgery (group A); tramadol postoperative, 100 mg IM immediately after surgery (group B); and saline (group C). We evaluated intensity of pain and analgesic consumption as was requested.
The analgesic efficacy measured as complete relief of pain at 24 hours was 86% in the preemptive tramadol compared with 70% and 36% for postoperative tramadol administration and control group. A significant reduction in the consumption of analgesics was seen in preoperative group as compared with the postoperative and control groups. Adverse events were minimal and similar in all groups.
This study suggests the preemptive use of tramadol as an alternative for the acute pain treatment after the removal of an impacted mandibular third molar carried out under local anesthesia.
我们比较了在局部麻醉下，于拔除下颌阻生第三磨牙手术前或术后立即给予曲马多的疗效。
在这项前瞻性、随机、对照、双盲的试点研究中，纳入了3组，每组20例患者：术前曲马多组，术前1小时肌肉注射（IM）100mg曲马多（A组）；术后曲马多组，术后立即IM注射100mg曲马多（B组）；以及生理盐水组（C组）。我们按要求评估了疼痛强度和镇痛药消耗量。
以24小时疼痛完全缓解来衡量，超前给予曲马多的镇痛效果为86%，而术后给予曲马多组和对照组分别为70%和36%。与术后组和对照组相比，术前组的镇痛药消耗量显著减少。所有组的不良事件均极少且相似。
本研究表明，对于在局部麻醉下拔除下颌阻生第三磨牙后的急性疼痛治疗，超前使用曲马多是一种替代方法。
