King Saud bin Abdulaziz University for Health Sciences, Saudi Arabia.
Respir Med. 2011 Nov;105(11):1755-60. doi: 10.1016/j.rmed.2011.07.007. Epub 2011 Aug 4.
Studies have suggested that ethnicity and environment may influence thyroid disease. We aim in this study to determine the prevalence of thyroid disease among Saudi (Arab) patients with laboratory-diagnosed obstructive sleep apnea (OSA) and the characteristics and predictors of thyroid disease associated with OSA.
Serum thyroid-stimulating hormone (TSH) and free-thyroxine (FT4) levels were measured in all patients referred to the sleep disorders center for an overnight sleep study. The levels were measured within 4 weeks of the sleep study. Type I attended polysomnography (PSG) was performed for all patients.
During the study period, 271 patients with OSA and a mean age of 48.7 ± 14.1 yr, a body mass index (BMI) of 37.7 ± 9.6 kg/m(2) and an AHI of 55.2 ± 37/hr as well as 76 non-OSA patients with a mean age of 40.8 ± 14.9 yr, a BMI of 33.7 ± 8.9 kg/m(2) and an AHI of 3.8 ± 3.1/hr underwent thyroid function tests. In the OSA patients, the prevalence of newly diagnosed clinical hypothyroidism was 0.4%, and the prevalence of newly diagnosed subclinical hypothyroidism was 11.1%. In the non-OSA patients, the prevalence of newly diagnosed clinical hypothyroidism was 1.4%, and the prevalence of newly diagnosed subclinical hypothyroidism was 4%. There were no cases of clinical or subclinical hyperthyroidism in the studied group. Female gender was the only predictor of clinical hypothyroidism.
In the OSA patients, the prevalence of newly diagnosed clinical hypothyroidism was low; however, subclinical hypothyroidism was common among patients with OSA.
研究表明，种族和环境可能影响甲状腺疾病。本研究旨在确定沙特（阿拉伯）实验室诊断为阻塞性睡眠呼吸暂停（OSA）的患者中甲状腺疾病的患病率，以及与 OSA 相关的甲状腺疾病的特征和预测因素。
所有被转介到睡眠障碍中心进行整夜睡眠研究的患者均测量血清促甲状腺激素（TSH）和游离甲状腺素（FT4）水平。这些水平是在睡眠研究后的 4 周内测量的。所有患者均进行了类型 I attended 多导睡眠图（PSG）。
在研究期间，271 例 OSA 患者的平均年龄为 48.7 ± 14.1 岁，体重指数（BMI）为 37.7 ± 9.6 kg/m2，呼吸暂停低通气指数（AHI）为 55.2 ± 37/hr，76 例非 OSA 患者的平均年龄为 40.8 ± 14.9 岁，BMI 为 33.7 ± 8.9 kg/m2，AHI 为 3.8 ± 3.1/hr，进行了甲状腺功能检查。在 OSA 患者中，新诊断的临床甲状腺功能减退症的患病率为 0.4%，新诊断的亚临床甲状腺功能减退症的患病率为 11.1%。在非 OSA 患者中，新诊断的临床甲状腺功能减退症的患病率为 1.4%，新诊断的亚临床甲状腺功能减退症的患病率为 4%。研究组中没有临床或亚临床甲状腺功能亢进症的病例。女性是临床甲状腺功能减退症的唯一预测因素。
在 OSA 患者中，新诊断的临床甲状腺功能减退症的患病率较低；然而，亚临床甲状腺功能减退症在 OSA 患者中很常见。
