Department of Animal Medicine and Surgery, Veterinary School, University of Murcia, 30100 Murcia, Spain.
Vet J. 2012 Jun;192(3):494-7. doi: 10.1016/j.tvjl.2011.06.040. Epub 2011 Aug 4.
Increased serum butyrylcholinesterase (BChE) activity is a feature of diabetes mellitus (DM) in humans and rats. The objective of this study was to evaluate serum BChE activity in diabetic dogs. The activity of the enzyme was assessed in three cohorts of animals: (1) dogs with naturally occurring DM (n=74); (2) clinically normal dogs (n=74); and (3) dogs with various other diseases (n=74). A statistically significant increase in BChE activity was found in the diabetic dogs (7.59 ± 2.9 kUI/L) compared with the clinically normal animals (6.12 ± 1.94 kUI/L; P<0.05), and with the dogs with other diseases (5.55 ± 2.06 kUI/L; P<0.01). Such increased activity could be the result of the altered glucose and lipid metabolism that occurs in DM.
血清丁酰胆碱酯酶（BChE）活性升高是人类和大鼠糖尿病（DM）的特征。本研究旨在评估糖尿病犬的血清 BChE 活性。评估了三组动物的酶活性：（1）患有自发性 DM 的犬（n=74）；（2）临床正常犬（n=74）；（3）患有其他各种疾病的犬（n=74）。与临床正常动物（6.12±1.94 kUI/L；P<0.05）和患有其他疾病的犬（5.55±2.06 kUI/L；P<0.01）相比，糖尿病犬的 BChE 活性明显升高（7.59±2.9 kUI/L）。这种活性增加可能是 DM 中发生的葡萄糖和脂质代谢改变的结果。
