Programa de Pós-Graduação em Neurociências, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Neurosci Lett. 2011 Sep 15;502(2):103-6. doi: 10.1016/j.neulet.2011.07.031. Epub 2011 Jul 28.
Neurotrophic factors regulate the survival and growth of neurons, and influence synaptic efficiency and plasticity. Several studies suggest the existence of a relationship between changes in neurotrophic levels and bipolar disorder (BD). The glial cell-line derived neurotrophic factor (GDNF) influences monoaminergic neurons and glial cells, but its role in BD patients is controversial. In order to elucidate it we evaluated plasma levels of GDNF in a sample of 70 BD patients (35 in mania and 35 in euthymia) and compared with 50 healthy controls matched for age, gender and educational levels. GDNF plasma levels were measured by enzyme-linked immunosorbent assay (ELISA). Patients were assessed by a Mini-International Neuropsychiatric Interview (MINI-plus), Young Mania and Hamilton Depression Rating Scales. Plasma GDNF levels were significantly increased in BD patients in euthymia compared with BD patients in mania and healthy controls (p<0.05). GDNF plasma levels were correlated with age (ρ=0.30, p<0.05) and negatively correlated with manic symptoms in BD patients (ρ=-0.54, p<0.05). Our results provide evidence that peripheral levels of GDNF are related with different mood states in BD, reinforcing the involvement of neurotrophic factors in its physiopathology.
神经营养因子调节神经元的存活和生长，并影响突触效率和可塑性。一些研究表明，神经营养因子水平的变化与双相情感障碍（BD）之间存在关系。胶质细胞系衍生的神经营养因子（GDNF）影响单胺能神经元和神经胶质细胞，但它在 BD 患者中的作用存在争议。为了阐明这一点，我们评估了 70 名 BD 患者（35 名躁狂症和 35 名缓解期）和 50 名年龄、性别和教育程度匹配的健康对照者的血浆 GDNF 水平。GDNF 血浆水平通过酶联免疫吸附试验（ELISA）测量。患者通过迷你国际神经精神病学访谈（MINI-plus）、Young 躁狂和汉密尔顿抑郁评定量表进行评估。与 BD 患者躁狂症和健康对照组相比，BD 患者缓解期的 GDNF 血浆水平显著升高（p<0.05）。GDNF 血浆水平与年龄呈正相关（ρ=0.30，p<0.05），与 BD 患者的躁狂症状呈负相关（ρ=-0.54，p<0.05）。我们的结果提供了证据，表明外周 GDNF 水平与 BD 中的不同情绪状态有关，这加强了神经营养因子在其病理生理学中的作用。
