Centro de Investigación y Estudios Avanzados en Salud Animal, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Estado de México, Toluca, Mexico.
Adv Parasitol. 2011;75:121-46. doi: 10.1016/B978-0-12-385863-4.00006-X.
The pathology of Chagas disease presents a complicated and diverse picture in humans. The major complications and destructive evolutionary outcomes of chronic infection by Trypanosoma cruzi in humans include ventricular fibrillation, thromboembolism and congestive heart failure. Studies in animal models and human patients have revealed the pathogenic mechanisms during disease progression, pathology of disease and features of protective immunity. Accordingly, several antigens, antigen-delivery vehicles and adjuvants have been tested to elicit immune protection to T. cruzi in experimental animals. This review summarizes the research efforts in vaccine development against Chagas disease during the past decade.
克氏锥虫感染的人类病理学表现复杂且多样。克氏锥虫慢性感染的主要并发症和破坏性进化结果包括心室纤维性颤动、血栓栓塞和充血性心力衰竭。在动物模型和人类患者中的研究揭示了疾病进展过程中的发病机制、疾病病理学和保护性免疫特征。因此，已经测试了几种抗原、抗原传递载体和佐剂，以在实验动物中引发针对克氏锥虫的免疫保护。本文综述了过去十年中针对克氏锥虫病的疫苗开发研究进展。
