Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Mol Cell Endocrinol. 2012 Jul 25;358(2):155-65. doi: 10.1016/j.mce.2011.07.027. Epub 2011 Jul 28.
During the early stages of pregnancy, fertilized embryos must attach to the uterine epithelium, invade into the underlying uterine stroma, and the stroma must then differentiate in a process termed decidualization in order for a successful pregnancy to be initiated. The steroid hormone progesterone (P4) is an integral mediator of these early pregnancy events, exerting its effects via the progesterone receptor (PR). Insights gained from the use of mouse models and genomic profiling has identified many of the key molecules enlisted by PR to execute the paradigm of early pregnancy. This review describes several of the molecules through which the PR exerts its pleiotropic effects including ligands, receptors, chaperones, signaling proteins and transcription factors. Understanding these molecules and their concatenation is of vital importance to our ability to clinically treat reproductive health problems like infertility and endometriosis.
在怀孕早期，受精卵必须附着在子宫上皮，侵入到下面的子宫基质中，基质然后必须分化，这个过程被称为蜕膜化，以便成功启动妊娠。甾体激素孕激素（P4）是这些早期妊娠事件的重要介质，通过孕激素受体（PR）发挥作用。使用小鼠模型和基因组分析获得的见解已经确定了 PR 用来执行早期妊娠范例的许多关键分子。本综述描述了 PR 发挥其多效作用的几种分子，包括配体、受体、伴侣蛋白、信号蛋白和转录因子。了解这些分子及其串联对于我们治疗生殖健康问题（如不孕和子宫内膜异位症）的能力至关重要。
