Park Wonhyoung, Lim Whasun, Kim Miji, Jang Hyewon, Park Soo Jin, Song Gwonhwa, Park Sunwoo
Department of Animal Science, Chungbuk National University, Cheongju 28644, Republic of Korea.
Department of Biological Sciences, College of Science, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Mol Cells. 2025 Jan;48(1):100164. doi: 10.1016/j.mocell.2024.100164. Epub 2024 Nov 29.
Despite the fact that endometriosis is a common gynecological disease that occurs in 10% of women of reproductive age, the pathogenesis and treatment strategy are not clear to date. Endometriosis patients are commonly characterized by adhesions in the pelvis or ovaries, which leads to prolonged inflammation in the abdominal cavity. To handle the chronic inflammation, changes of immune cells, including T cells, NK cells, and macrophage, are accompanied. Therefore, diverse cytokines and adhesions of the abdominal cavity lead to poor quality of ovarian follicles, inappropriate response to the hormone, and infertility. This review will guide researchers to summarize the molecular changes and identify new treatment strategies for endometriosis-mediated inflammation and pregnancy failure.
尽管子宫内膜异位症是一种常见的妇科疾病，在10%的育龄女性中发病，但迄今为止其发病机制和治疗策略仍不明确。子宫内膜异位症患者通常表现为盆腔或卵巢粘连，这会导致腹腔内长期炎症。为应对慢性炎症，免疫细胞（包括T细胞、NK细胞和巨噬细胞）会发生变化。因此，多种细胞因子和腹腔粘连会导致卵巢卵泡质量差、对激素反应不当以及不孕。本综述将指导研究人员总结分子变化，并确定针对子宫内膜异位症介导的炎症和妊娠失败的新治疗策略。
