Center of Clinical Laboratory, Zhongshan Hospital, Xiamen University, Xiamen, 361004, China.
Int Immunopharmacol. 2011 Nov;11(11):1850-4. doi: 10.1016/j.intimp.2011.07.015. Epub 2011 Aug 5.
We investigated the changes in characteristics of neutrophil CD11b, monocyte CD11b, platelet CD62P, endothelin (ET), and neutrophil CD178 in patients with coronary heart disease (CHD) before and after primary coronary stenting. A total of 41 patients with CHD who underwent coronary stenting and 40 control subjects were enrolled in the study. In CHD patients, peripheral blood samples were taken 24 h before and 30 min, 24 h, and 72 h after successful coronary stenting. All markers were significantly elevated in patients with CHD compared with controls (P<0.05). Time-course studies revealed that the expressions of neutrophil CD11b, monocyte CD11b, platelet CD62P, and ET were lower at 30 min post-operation (PO) compared with that at 24 h before operation (BO) (P<0.05). All levels significantly increased from 30 min PO to 24 h PO (P<0.05) and decreased thereafter until 72 h PO (P>0.05). Time course changes in neutrophil CD11b levels after coronary stenting were significantly higher in patients with unstable angina pectoris than in patients with stable angina pectoris (P<0.05). CD11b levels were related to CD62P in patients with CHD (P<0.05). Neutrophil CD11b and monocyte CD11b levels were significantly increased in patients with CHD who underwent coronary stenting compared with controls (P<0.05). Results show that CD11b levels increased, meanwhile, the levels of CD62P and ET increased in CHD patients after coronary stenting. In addition, neutrophil CD178 levels of apoptosis factor in patients, which is important for regression of inflammation, remained high for a period of time after coronary stenting.
我们研究了经皮冠状动脉支架置入术（PCI）前后冠心病（CHD）患者中性粒细胞 CD11b、单核细胞 CD11b、血小板 CD62P、内皮素（ET）和中性粒细胞 CD178 特征的变化。共纳入 41 例行 PCI 的 CHD 患者和 40 例对照者。在 CHD 患者中，分别于 PCI 前 24 h 及术后 30 min、24 h 和 72 h 取外周血标本。与对照组相比，CHD 患者的所有标志物均显著升高（P<0.05）。时间进程研究显示，与术前 24 h 相比，术后 30 min 时中性粒细胞 CD11b、单核细胞 CD11b、血小板 CD62P 和 ET 的表达水平较低（P<0.05）。所有水平均从术后 30 min 升高至术后 24 h（P<0.05），随后直至术后 72 h 下降（P>0.05）。与稳定型心绞痛患者相比，不稳定型心绞痛患者 PCI 后中性粒细胞 CD11b 水平的时间进程变化更高（P<0.05）。CD11b 水平与 CHD 患者的 CD62P 相关（P<0.05）。与对照组相比，行 PCI 的 CHD 患者的中性粒细胞 CD11b 和单核细胞 CD11b 水平显著升高（P<0.05）。结果表明，CHD 患者 PCI 后 CD11b 水平升高，同时 CD62P 和 ET 水平升高。此外，CHD 患者中与炎症消退有关的凋亡因子中性粒细胞 CD178 水平在 PCI 后一段时间内仍保持较高水平。
